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“Straight away he started making problems. Lesley’s relationship faltered, and she met a new man - labourer Lee Ford, who moved into the family home. We were happy, we were making it work.”īut unfortunately, the happy state of affairs wasn’t to last.
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I’d play football with the boys and take them to watch my dad working - he used a digger and they loved that. I would see the kids for days out, they’d come and stay with me at the weekend. Michael moved out of the family home, but remained on good terms with Lesley. “That was hard, but we knew we had to make it work for the kids. Cracks began to appear in the relationship, and Michael discovered that Lesley had become involved with another man. The boys were cheeky but well behaved, and the girls were sweet and loving, just like their mum.”īut the pressure of looking after a big family began to take it’s toll. “It was all football and dolls in our house. We wanted a big family and that’s what we had.” “We had four kids, so it was a little bit chaotic, but we were so happy. I took to fatherhood really well and Lesley was a brilliant mum,”īaby Anne Marie followed quickly, and then came the two boys - Stephen Paul and Craig Jonathan. She was a lovely, tiny little thing, just six pounds. Nothing, apart from the day I married Lesley, had ever come close. ‘When I held her in my arms for the first time, I was over the moon. Sarah Jane was born in January 1983 and Michael was overjoyed. But she wouldn’t buy a new one, or even let me buy one, she got it from the charity shop. “She had a beautiful white dress on the day. She was a lovely girl, she would do anything for anyone.” Michael, who works for a delivery company, was 21 and Lesley just 19 when they got married. One day she got off at my stop and I walked her home. All rights reserved.Michael, 55, was just 21 when he met future wife Lesley, who like him, grew up in Telford in Shropshire.
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However, our novel observation that MRL may possess an impaired compensated hypertrophy response makes the MRL mouse strain an interesting model in the study of cardiac hypertrophy.Ĭardiac regeneration Hypertrophy MRL mice Myocardial infarction.Ĭopyright © 2014 Elsevier Inc. The prospect of cardiac regeneration after ischemia in MRL mice seems to have attenuated interest, given the multiple negative studies and the promise of stem cell cardiac regeneration. However, unlike prior studies, we matched initial infarct size in MRL and C57 mice, used high frequency echocardiography, and histological analysis to reach this conclusion. Therefore, we conclude that MRL mice do not exhibit regeneration of the LV or enhanced functional improvement in response to coronary ligation. Our results show that contrary to prior reports of cardiac regenerations, MRL mice progress to heart failure more rapidly following I/R injury as marked by a significant decrease in LVEF, increase in LVEDV, LV mass, individual myocyte size, and fibrosis in the post-ischemic myocardium. Hearts were also analyzed histologically for individual cardiomyocyte hypertrophy and cardiac fibrosis. Cardiac function was evaluated by echocardiography at 24 hours post-ischemia and weekly for 13 weeks thereafter. Male MRL/MpJ+/+ and C57BL/6 mice underwent left coronary artery ligation followed by reperfusion.
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Therefore, we evaluated the cardiac regenerative wound-healing response and functional recovery of MRL mice compared to C57 mice, in response to a clinically relevant left ventricular (LV) coronary ligation. Although the MRL mouse has been reported to exhibit minimal scarring and subsequent cardiac regeneration after cryoinjury of the right ventricle, multiple studies have been unable to replicate this cardiac regenerative capacity after both cryogenic and coronary ligation cardiac injury. The cardiac regenerative capacity of MRL/MpJ mouse remains a controversy.